Prevalence Of Mutations

 
Manifestation
Mutation
Germline
Somatic
Carcinoma
T632I
2
58
2
62
M453T
4
49
3
56
R450H
25
25
A623V
1
21
22
F631L
1
20
1
22
D619G
2
19
21
P162A
21
21
D633Y
1
18
1
20
I568T
2
17
1
20
L629F
1
19
20
I486F
14
2
16
D633E
1
14
15
S281N
3
12
15
D633H
13
1
14
I630L
1
12
1
14
I486M
13
13
A623S
7
3
10
L512Q
2
8
10
C41S
9
9
L512R
7
1
8
R109Q
8
8
T632A
7
1
8
P68S
7
7
S425I
7
7
S505N
3
4
7
M463V
4
2
6
S281I
6
6
S281T
6
6
F631I
4
1
5
G431S
3
2
5
V656F
5
5
A428V
2
2
4
A553T
4
4
I568F
3
1
4
P639S
2
2
4
S505R
2
2
4
T655X
4
4
W546X
4
4
-613-
3
3
C390F
3
3
C390W
3
3
D403N
3
3
D410N
3
3
G132R
3
3
M626I
2
1
3
P264S
3
3
R609X
3
3
V597F
2
1
3
V689G
3
3
Y601N
3
3
A623I
2
2
E34K
2
2
E575K
2
2
F525S
2
2
F631V
2
2
G245S
2
2
I486N
1
1
2
I640T
2
2
L252P
2
2
L653V
2
2
M453R
2
2
M527T
2
2
N372T
2
2
N406S
2
2
N633E
2
2
R310C
2
2
R519C
2
2
R531W
2
2
S305R
2
2
V473I
2
2
V509A
2
2
V597L
1
1
2
W488R
2
2
Y613C
2
2
-0-
1
1
-123-
1
1
-157-
1
1
-308-
1
1
-317-
1
1
-339-
1
1
A170A
1
1
A204V
1
1
A275T
1
1
A428I
1
1
A485V
1
1
A526T
1
1
A593N
1
1
A593V
1
1
A623C
1
1
A623F
1
1
A623G
1
1
A627V
1
1
A644D
1
1
A647V
1
1
A684D
1
1
C176R
1
1
C283Y
1
1
C31X
1
1
C408R
1
1
C41-
1
1
C462R
1
1
C600R
1
1
C636W
1
1
C672T
1
1
C672W
1
1
D403-
1
1
D403A
1
1
D617Y
1
1
D633A
1
1
D670S
1
1
E758K
1
1
F525L
1
1
F631C
1
1
F631S
1
1
F666L
1
1
F696C
1
1
G498S
1
1
G544E
1
1
H271N
1
1
I167M
1
1
I167N
1
1
I568V
1
1
I583T
1
1
I630M
1
1
I635V
1
1
I640K
1
1
I661X
1
1
I691F
1
1
K183N
1
1
K183R
1
1
K58-
1
1
K618X
1
1
K700E
1
1
L267F
1
1
L467P
1
1
L512M
1
1
L555X
1
1
L57E
1
1
L665F
1
1
L677V
1
1
M465-
1
1
M572A
1
1
N406-
1
1
N432D
1
1
N650Y
1
1
N670S
1
1
P162L
1
1
P162S
1
1
P27T
1
1
P449L
1
1
P51Q
1
1
P556R
1
1
P639A
1
1
P668L
1
1
Q324X
1
1
Q33P
1
1
Q489H
1
1
Q8H
1
1
Q90P
1
1
R46P
1
1
R519G
1
1
R528C
1
1
R528S
1
1
R609L
1
1
R609Q
1
1
S166X
1
1
S234P
1
1
S562G
1
1
S745C
1
1
T145I
1
1
T477I
1
1
T607I
1
1
T620I
1
1
T655C
1
1
V392-
1
1
V424F
1
1
V424I
1
1
V87L
1
1
Y444X
1
1
Y446C
1
1
Y466C
1
1
Y601P
1
1
TOTALS
268
414
21
703